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Copy pathv3.2.0_optimized.sbml
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v3.2.0_optimized.sbml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" level="3" version="1">
<model id="cell_cycle_v3_2_0" substanceUnits="substance" timeUnits="second" volumeUnits="volume" areaUnits="area" lengthUnits="metre" extentUnits="substance">
<listOfUnitDefinitions>
<unitDefinition id="volume">
<listOfUnits>
<unit kind="litre" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="substance">
<listOfUnits>
<unit kind="mole" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="area">
<listOfUnits>
<unit kind="metre" exponent="2" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="cell" spatialDimensions="3" size="1" units="volume" constant="true"/>
</listOfCompartments>
<listOfSpecies>
<species id="_cell__CCND" name="_cell__CCND" compartment="cell" initialConcentration="3.857236589" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE_CDKN1A_B_" name="_cell__CCNE_CDKN1A_B_" compartment="cell" initialConcentration="0.366015703" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_RB1_Ser332u_" name="_cell__E2F_DBD_RB1_Ser332u_" compartment="cell" initialConcentration="0.099199998" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_RB1_Ser332p_" name="_cell__E2F_DBD_RB1_Ser332p_" compartment="cell" initialConcentration="0.034799999" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA_CDKN1A_B_" name="_cell__CCNA_CDKN1A_B_" compartment="cell" initialConcentration="0.055205093" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_" name="_cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_" compartment="cell" initialConcentration="0.236008538" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" name="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" compartment="cell" initialConcentration="0.208999997" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" name="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" compartment="cell" initialConcentration="0.046737014" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__RB1_E2F_Ser807_Ser811u_" name="_cell__RB1_E2F_Ser807_Ser811u_" compartment="cell" initialConcentration="0.729492942" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__RB1_E2F_Ser807_Ser811p_" name="_cell__RB1_E2F_Ser807_Ser811p_" compartment="cell" initialConcentration="3.096243575" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__PPP2R2B_ENSA_ARPP19_" name="_cell__PPP2R2B_ENSA_ARPP19_" compartment="cell" initialConcentration="0.001150224" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_FZR1_CDC20_Ser355u_" name="_cell__APC_FBXO5_FZR1_CDC20_Ser355u_" compartment="cell" initialConcentration="36.19062603" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDC20_APC_" name="_cell__CDC20_APC_" compartment="cell" initialConcentration="0.021600039" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355p__CDC20_APC_1_" name="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355p__CDC20_APC_1_" compartment="cell" initialConcentration="0.132083079" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_FZR1_CDC20_Ser355p_" name="_cell__APC_FBXO5_FZR1_CDC20_Ser355p_" compartment="cell" initialConcentration="4.142409633" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355u__FZR1_APC_1_FBXO5_nTermu_" name="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355u__FZR1_APC_1_FBXO5_nTermu_" compartment="cell" initialConcentration="0.239893982" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FZR1_APC_FBXO5_nTermu_" name="_cell__FZR1_APC_FBXO5_nTermu_" compartment="cell" initialConcentration="0.0207" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FZR1_APC_FBXO5_nTermp_" name="_cell__FZR1_APC_FBXO5_nTermp_" compartment="cell" initialConcentration="0.091360525" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_1_FZR1_CDC20_2_Ser355u__FBXO5_APC_1_FZR1_3_Ser182u__FZR1_APC_2_FBXO5_3_nTermu_" name="_cell__APC_FBXO5_1_FZR1_CDC20_2_Ser355u__FBXO5_APC_1_FZR1_3_Ser182u__FZR1_APC_2_FBXO5_3_nTermu_" compartment="cell" initialConcentration="0.015962941" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FBXO5_APC_FZR1_Ser182u_" name="_cell__FBXO5_APC_FZR1_Ser182u_" compartment="cell" initialConcentration="0.492130281" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_1_FZR1_CDC20_2_Ser355p__FBXO5_APC_1_FZR1_3_Ser182u__FZR1_APC_2_FBXO5_3_nTermu_" name="_cell__APC_FBXO5_1_FZR1_CDC20_2_Ser355p__FBXO5_APC_1_FZR1_3_Ser182u__FZR1_APC_2_FBXO5_3_nTermu_" compartment="cell" initialConcentration="0.103999998" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355p__FZR1_APC_1_FBXO5_nTermu_" name="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355p__FZR1_APC_1_FBXO5_nTermu_" compartment="cell" initialConcentration="0.019437575" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FBXO5_APC_FZR1_Ser182p_" name="_cell__FBXO5_APC_FZR1_Ser182p_" compartment="cell" initialConcentration="0.026115125" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FOXM1_DBD_Thr600u_" name="_cell__FOXM1_DBD_Thr600u_" compartment="cell" initialConcentration="0.003940009" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FOXM1_DBD_Thr600p_" name="_cell__FOXM1_DBD_Thr600p_" compartment="cell" initialConcentration="0.062900115" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" name="_cell__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" compartment="cell" initialConcentration="1.9e-07" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNB_promoter_FOXM1_" name="_cell__CCNB_promoter_FOXM1_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDC20_promoter_FOXM1_" name="_cell__CDC20_promoter_FOXM1_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDC20_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" name="_cell__CDC20_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__WEE1_Ser123u_" name="_cell__WEE1_Ser123u_" compartment="cell" initialConcentration="0.263482622" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_" name="_cell__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_" compartment="cell" initialConcentration="0.002167134" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__WEE1_Ser123p_" name="_cell__WEE1_Ser123p_" compartment="cell" initialConcentration="6.381711542" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDC25_pSitesp_" name="_cell__CDC25_pSitesp_" compartment="cell" initialConcentration="0.186941482" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDC25_pSitesu_" name="_cell__CDC25_pSitesu_" compartment="cell" initialConcentration="0.007048923" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__MASTL_Thr198u_" name="_cell__MASTL_Thr198u_" compartment="cell" initialConcentration="0.060676609" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__MASTL_Thr198p_" name="_cell__MASTL_Thr198p_" compartment="cell" initialConcentration="3.084642742" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__ENSA_ARPP19_PPP2R2B_Ser62_Ser67u_" name="_cell__ENSA_ARPP19_PPP2R2B_Ser62_Ser67u_" compartment="cell" initialConcentration="2.862084705" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__ENSA_ARPP19_PPP2R2B_Ser62_Ser67p_" name="_cell__ENSA_ARPP19_PPP2R2B_Ser62_Ser67p_" compartment="cell" initialConcentration="0.968695703" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__ENSA_ARPP19_PPP2R2B_1_Ser62_Ser67p__PPP2R2B_ENSA_ARPP19_1_" name="_cell__ENSA_ARPP19_PPP2R2B_1_Ser62_Ser67p__PPP2R2B_ENSA_ARPP19_1_" compartment="cell" initialConcentration="0.265177693" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE_promoter_E2F_" name="_cell__CCNE_promoter_E2F_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA_promoter_E2F_" name="_cell__CCNA_promoter_E2F_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_promoter_E2F_" name="_cell__E2F_promoter_E2F_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FBXO5_promoter_E2F_" name="_cell__FBXO5_promoter_E2F_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FOXM1_promoter_E2F_" name="_cell__FOXM1_promoter_E2F_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" name="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" name="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" name="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" name="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__SKP2" name="_cell__SKP2" compartment="cell" initialConcentration="1" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__TP53_DBD_Ser15p_" name="_cell__TP53_DBD_Ser15p_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDKN1A_promoter_TP53_" name="_cell__CDKN1A_promoter_TP53_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FOXO_DBD_" name="_cell__FOXO_DBD_" compartment="cell" initialConcentration="1" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDKN1B_promoter_FOXO_" name="_cell__CDKN1B_promoter_FOXO_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDKN1A_promoter_TP53_1__TP53_DBD_1_Ser15p_" name="_cell__CDKN1A_promoter_TP53_1__TP53_DBD_1_Ser15p_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDKN1A_CCNE_A_B_Ser130u_" name="_cell__CDKN1A_CCNE_A_B_Ser130u_" compartment="cell" initialConcentration="0.173668515" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDKN1B_promoter_FOXO_1__FOXO_DBD_1_" name="_cell__CDKN1B_promoter_FOXO_1__FOXO_DBD_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDKN1B_CCNE_A_Thr187u_" name="_cell__CDKN1B_CCNE_A_Thr187u_" compartment="cell" initialConcentration="0.021533874" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_" name="_cell__CCNA_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_" compartment="cell" initialConcentration="0.045916081" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_" name="_cell__CCNE_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_" compartment="cell" initialConcentration="0.00049177" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_" name="_cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_" compartment="cell" initialConcentration="0.069994412" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_" name="_cell__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_" compartment="cell" initialConcentration="0.003069893" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDKN1A_CCNE_A_B_Ser130p_" name="_cell__CDKN1A_CCNE_A_B_Ser130p_" compartment="cell" initialConcentration="0.099828935" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_" name="_cell__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_" compartment="cell" initialConcentration="0.028384822" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_" name="_cell__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_" compartment="cell" initialConcentration="0.003409842" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDKN1B_CCNE_A_Thr187p_" name="_cell__CDKN1B_CCNE_A_Thr187p_" compartment="cell" initialConcentration="0.090063602" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_" name="_cell__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_" compartment="cell" initialConcentration="0.033142717" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_" name="_cell__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_" compartment="cell" initialConcentration="0.005444253" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
</listOfSpecies>
<listOfParameters>
<parameter id="kPhRbD" value="0.001088481" constant="true"/>
<parameter id="kPhRbE" value="0.026024343" constant="true"/>
<parameter id="kDpRb" value="0.0057882" constant="true"/>
<parameter id="kPhRb" value="0.023155243" constant="true"/>
<parameter id="kSyCe1" value="0.000139498" constant="true"/>
<parameter id="kSyCe2" value="1.045823052" constant="true"/>
<parameter id="kDeCe" value="0.000979552" constant="true"/>
<parameter id="kDiE2fRb" value="7.53501e-05" constant="true"/>
<parameter id="kAsE2fRb" value="0.597101762" constant="true"/>
<parameter id="kSyE2f1" value="6.30687e-05" constant="true"/>
<parameter id="kSyE2f2" value="6.64568184" constant="true"/>
<parameter id="kDeE2f1" value="3.31498e-05" constant="true"/>
<parameter id="kDeE2f2" value="0.001508046" constant="true"/>
<parameter id="kPhE2f" value="0.004546695" constant="true"/>
<parameter id="kDpE2f2" value="0.076167436" constant="true"/>
<parameter id="kSyEmi1" value="0.000322045" constant="true"/>
<parameter id="kSyEmi2" value="15.32670782" constant="true"/>
<parameter id="kDeEmi1" value="1.64574e-05" constant="true"/>
<parameter id="kDeEmi2" value="0.001060284" constant="true"/>
<parameter id="kDeEmi3" value="0.01375476" constant="true"/>
<parameter id="kPhEmiA" value="3.79063e-07" constant="true"/>
<parameter id="kPhEmiB" value="0.002768967" constant="true"/>
<parameter id="kDpEmi" value="4.26272e-08" constant="true"/>
<parameter id="kSyCa1" value="6.46385e-06" constant="true"/>
<parameter id="kSyCa2" value="0.139555845" constant="true"/>
<parameter id="kDeCa1" value="6.93149e-08" constant="true"/>
<parameter id="kDeCa2" value="0.002290617" constant="true"/>
<parameter id="kDeCa3" value="0.004191463" constant="true"/>
<parameter id="kDpCdh" value="0.002529724" constant="true"/>
<parameter id="kPhCdhA" value="0.003687191" constant="true"/>
<parameter id="kPhCdhE" value="6.93e-05" constant="true"/>
<parameter id="kPhCdhB" value="0.002543414" constant="true"/>
<parameter id="kDiACE" value="0.00178481" constant="true"/>
<parameter id="kAsACE" value="0.035977865" constant="true"/>
<parameter id="kDiACdh" value="3.47e-06" constant="true"/>
<parameter id="kAsACdh" value="0.003859147" constant="true"/>
<parameter id="kPhCeA" value="6.93001e-05" constant="true"/>
<parameter id="kPhCeE" value="0.000693001" constant="true"/>
<parameter id="kPhFoxE" value="6.93e-06" constant="true"/>
<parameter id="kPhFoxA" value="5.28592e-05" constant="true"/>
<parameter id="kPhFoxB" value="0.005815083" constant="true"/>
<parameter id="kDpFox" value="2.04339e-05" constant="true"/>
<parameter id="kSyCb1" value="6.20973e-06" constant="true"/>
<parameter id="kSyCb2" value="0.38857712" constant="true"/>
<parameter id="kDeCb1" value="6.31596e-06" constant="true"/>
<parameter id="kDeCb2" value="0.000155053" constant="true"/>
<parameter id="kDeCb3" value="0.001019924" constant="true"/>
<parameter id="kPhEnsa" value="0.000169614" constant="true"/>
<parameter id="kDpEnsa" value="0.001595053" constant="true"/>
<parameter id="kPhGw" value="0.003018672" constant="true"/>
<parameter id="kDpGw1" value="0.003052087" constant="true"/>
<parameter id="kDpGw2" value="0.012744545" constant="true"/>
<parameter id="kWee1" value="6.94414e-07" constant="true"/>
<parameter id="kWee2" value="0.001065984" constant="true"/>
<parameter id="kPhWeeA" value="0.000834151" constant="true"/>
<parameter id="kPhWeeB" value="0.071921364" constant="true"/>
<parameter id="kDpWee" value="0.068578828" constant="true"/>
<parameter id="kCdc25_1" value="2.71514e-05" constant="true"/>
<parameter id="kCdc25_2" value="0.021452792" constant="true"/>
<parameter id="kDpCdc25" value="0.024031313" constant="true"/>
<parameter id="kDipEB55" value="4.71e-07" constant="true"/>
<parameter id="kAspEB55" value="3.950103658" constant="true"/>
<parameter id="kSyCdc_1" value="2.11115e-06" constant="true"/>
<parameter id="kSyCdc_2" value="5.257399897" constant="true"/>
<parameter id="kDeCdc_1" value="2.77e-07" constant="true"/>
<parameter id="kDeCdc_2" value="2.77027e-06" constant="true"/>
<parameter id="kDipACdc" value="1.08437e-05" constant="true"/>
<parameter id="kAspACdc" value="0.003623498" constant="true"/>
<parameter id="kPhApcA" value="0.000693001" constant="true"/>
<parameter id="kDpApc_1" value="0" constant="true"/>
<parameter id="kDpApc_2" value="2.586986386" constant="true"/>
<parameter id="kSyFox1" value="7.09943e-07" constant="true"/>
<parameter id="kSyFox2" value="0.052755808" constant="true"/>
<parameter id="kDeFox1" value="8.71115e-07" constant="true"/>
<parameter id="kDeFox2" value="0.030644773" constant="true"/>
<parameter id="kAsEPx" value="0.039441855" constant="true"/>
<parameter id="kDiEPx" value="0.010007457" constant="true"/>
<parameter id="kAsFPcb" value="0.43202553" constant="true"/>
<parameter id="kDiFPcb" value="0.028463248" constant="true"/>
<parameter id="kAsFPcdc" value="0.034996662" constant="true"/>
<parameter id="kDiFPcdc" value="0.191486631" constant="true"/>
<parameter id="kPhC25B" value="0.018451055" constant="true"/>
<parameter id="kPhCAEE" value="0.00454289" constant="true"/>
<parameter id="kPhCAEA" value="0.020747153" constant="true"/>
<parameter id="kPhCAEB" value="0.082332189" constant="true"/>
<parameter id="kDpE2f1" value="0" constant="true"/>
<parameter id="kPhC25A" value="0" constant="true"/>
<parameter id="kSySkp2" value="0.000485827" constant="true"/>
<parameter id="kDeSkp2_1" value="0.000340855" constant="true"/>
<parameter id="kDeSkp2_2" value="0.029577557" constant="true"/>
<parameter id="kAsTP53PCDKN1A" value="0.486795757" constant="true"/>
<parameter id="kDiTP53PCDKN1A" value="0.095030071" constant="true"/>
<parameter id="kSyCDKN1A_1" value="7.6538e-05" constant="true"/>
<parameter id="kSyCDKN1A_2" value="2.79194512" constant="true"/>
<parameter id="kDeCDKN1A_1" value="0.000413049" constant="true"/>
<parameter id="kDeCDKN1A_2" value="0.00025" constant="true"/>
<parameter id="kAsCdkn1aC" value="0.062723053" constant="true"/>
<parameter id="kDiCdkn1aC" value="0.000380578" constant="true"/>
<parameter id="kPhCDKN1AByCe" value="5.02071e-05" constant="true"/>
<parameter id="kPhCDKN1AByCa" value="0.000115077" constant="true"/>
<parameter id="kPhCDKN1AByCb" value="0.000403404" constant="true"/>
<parameter id="kDpCDKN1A" value="0.019999999" constant="true"/>
<parameter id="kAsFOXOPCDKN1B" value="0.56824615" constant="true"/>
<parameter id="kDiFOXOPCDKN1B" value="0.0015" constant="true"/>
<parameter id="kSyCDKN1B_1" value="2.27379e-05" constant="true"/>
<parameter id="kSyCDKN1B_2" value="0.203819947" constant="true"/>
<parameter id="kDeCDKN1B_1" value="0.000251363" constant="true"/>
<parameter id="kDeCDKN1B_2" value="0.001056432" constant="true"/>
<parameter id="kAsCdkn1bC" value="0.004161339" constant="true"/>
<parameter id="kDiCdkn1bC" value="6.52055e-05" constant="true"/>
<parameter id="kPhCDKN1BByCe" value="0.051862418" constant="true"/>
<parameter id="kPhCDKN1BByCa" value="0.0005" constant="true"/>
<parameter id="kPhCDKN1BByCb" value="5.04534e-06" constant="true"/>
<parameter id="kDpCDKN1B" value="0.014756773" constant="true"/>
<parameter id="_InitialConc1" value="1" constant="true"/>
<parameter id="_InitialConc2" value="0.23224914" constant="true"/>
<parameter id="_InitialConc3" value="0.018479024" constant="true"/>
<parameter id="_InitialConc4" value="3.8081857e-05" constant="true"/>
<parameter id="_InitialConc5" value="0.0070284949" constant="true"/>
<parameter id="_InitialConc6" value="0.0018823629" constant="true"/>
<parameter id="_InitialConc7" value="0.071461332" constant="true"/>
<parameter id="_InitialConc8" value="0.00015053859" constant="true"/>
<parameter id="_InitialConc9" value="0.087642687" constant="true"/>
<parameter id="_InitialConc10" value="0.84074544" constant="true"/>
<parameter id="_InitialConc11" value="0.077191625" constant="true"/>
<parameter id="_InitialConc12" value="4.0287133" constant="true"/>
<parameter id="_InitialConc13" value="0.22995279" constant="true"/>
<parameter id="_InitialConc14" value="0.069890078" constant="true"/>
<parameter id="_InitialConc15" value="0.063091065" constant="true"/>
<parameter id="_InitialConc16" value="0.71354419" constant="true"/>
<parameter id="_InitialConc17" value="0.00057134095" constant="true"/>
<parameter id="_InitialConc18" value="0.16112308" constant="true"/>
<parameter id="_InitialConc19" value="0.10894131" constant="true"/>
<parameter id="_InitialConc20" value="0.00071781614" constant="true"/>
<parameter id="_InitialConc21" value="0.0022125471" constant="true"/>
<parameter id="_InitialConc22" value="0.013607533" constant="true"/>
<parameter id="_InitialConc23" value="1.8804937e-05" constant="true"/>
<parameter id="_InitialConc24" value="0.0055647336" constant="true"/>
<parameter id="_InitialConc25" value="0.00038111617" constant="true"/>
<parameter id="_InitialConc26" value="1.9032592e-07" constant="true"/>
<parameter id="_InitialConc27" value="9.9809674e-05" constant="true"/>
<parameter id="_InitialConc28" value="9.9923815e-05" constant="true"/>
<parameter id="_InitialConc29" value="7.6185347e-08" constant="true"/>
<parameter id="_InitialConc30" value="0.98044163" constant="true"/>
<parameter id="_InitialConc31" value="0.0075129148" constant="true"/>
<parameter id="_InitialConc32" value="0.019558367" constant="true"/>
<parameter id="_InitialConc33" value="0.018438067" constant="true"/>
<parameter id="_InitialConc34" value="0.98156193" constant="true"/>
<parameter id="_InitialConc35" value="0.99752571" constant="true"/>
<parameter id="_InitialConc36" value="0.002474295" constant="true"/>
<parameter id="_InitialConc37" value="0.82686306" constant="true"/>
<parameter id="_InitialConc38" value="0.00032856116" constant="true"/>
<parameter id="_InitialConc39" value="0.17280837" constant="true"/>
<parameter id="_InitialConc40" value="8.4479024e-05" constant="true"/>
<parameter id="_InitialConc41" value="8.4479024e-05" constant="true"/>
<parameter id="_InitialConc42" value="8.4479024e-05" constant="true"/>
<parameter id="_InitialConc43" value="8.4479024e-05" constant="true"/>
<parameter id="_InitialConc44" value="8.4479024e-05" constant="true"/>
<parameter id="_InitialConc45" value="1.5520976e-05" constant="true"/>
<parameter id="_InitialConc46" value="1.5520976e-05" constant="true"/>
<parameter id="_InitialConc47" value="1.5520976e-05" constant="true"/>
<parameter id="_InitialConc48" value="1.5520976e-05" constant="true"/>
<parameter id="_InitialConc49" value="1.5520976e-05" constant="true"/>
<parameter id="_InitialConc50" value="0" constant="true"/>
<parameter id="_InitialConc51" value="0" constant="true"/>
<parameter id="_InitialConc52" value="0" constant="true"/>
<parameter id="_InitialConc53" value="0" constant="true"/>
<parameter id="_InitialConc54" value="0" constant="true"/>
<parameter id="_InitialConc55" value="1" constant="true"/>
<parameter id="_InitialConc56" value="0" constant="true"/>
<parameter id="_InitialConc57" value="0.0001" constant="true"/>
<parameter id="_InitialConc58" value="1" constant="true"/>
<parameter id="_InitialConc59" value="0.0001" constant="true"/>
<parameter id="_rateLaw1" value="0" constant="true"/>
<parameter id="tCCNE" constant="false"/>
<parameter id="tCCNA" constant="false"/>
<parameter id="tCCNB" constant="false"/>
<parameter id="tCDKN1A" constant="false"/>
<parameter id="tCDKN1B" constant="false"/>
<parameter id="tSKP2" constant="false"/>
<parameter id="ApcCdh" constant="false"/>
</listOfParameters>
<listOfRules>
<assignmentRule variable="tCCNE">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _cell__CCNE_CDKN1A_B_ </ci>
<ci> _cell__CCNE_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _cell__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _cell__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tCCNA">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _cell__CCNA_CDKN1A_B_ </ci>
<ci> _cell__CCNA_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _cell__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _cell__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tCCNB">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_ </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_ </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tCDKN1A">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _cell__CDKN1A_CCNE_A_B_Ser130u_ </ci>
<ci> _cell__CCNA_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _cell__CCNE_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _cell__CDKN1A_CCNE_A_B_Ser130p_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tCDKN1B">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _cell__CDKN1B_CCNE_A_Thr187u_ </ci>
<ci> _cell__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _cell__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _cell__CDKN1B_CCNE_A_Thr187p_ </ci>
<ci> _cell__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
<ci> _cell__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tSKP2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<cn> 0 </cn>
<ci> _cell__SKP2 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="ApcCdh">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _cell__APC_FBXO5_FZR1_CDC20_1_Ser355u__FZR1_APC_1_FBXO5_nTermu_ </ci>
<ci> _cell__APC_FBXO5_FZR1_CDC20_1_Ser355p__FZR1_APC_1_FBXO5_nTermu_ </ci>
</apply>
</math>
</assignmentRule>
</listOfRules>
<listOfReactions>
<reaction id="R1" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kSyE2f1 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R2" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__FOXM1_DBD_Thr600p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_promoter_FOXM1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kAsFPcb </ci>
<ci> _cell__FOXM1_DBD_Thr600p_ </ci>
<ci> _cell__CCNB_promoter_FOXM1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R3" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__FOXM1_DBD_Thr600p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_promoter_FOXM1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDiFPcb </ci>
<ci> _cell__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R4" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kSyE2f2 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R5" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kSyE2f2 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R6" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R7" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_RB1_Ser332p_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R8" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R9" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R10" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNE_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R11" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R12" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R13" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__FBXO5_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R14" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__FOXM1_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R15" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNE_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R16" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R17" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R18" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__FBXO5_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R19" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__FOXM1_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R20" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCND" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCND" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRbD </ci>
<ci> _cell__CCND </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R21" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCND" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCND" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRbD </ci>
<ci> _cell__CCND </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R22" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNE_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNE_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRbE </ci>
<ci> _cell__CCNE_CDKN1A_B_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R23" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNE_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNE_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRbE </ci>
<ci> _cell__CCNE_CDKN1A_B_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R24" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
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<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRb </ci>
<ci> _cell__CCNA_CDKN1A_B_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R25" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
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<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRb </ci>
<ci> _cell__CCNA_CDKN1A_B_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R26" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRb </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R27" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRb </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R28" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
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<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__E2F_DBD_RB1_Ser332u_ </ci>
<ci> _cell__CCNA_CDKN1A_B_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R29" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA_CDKN1A_B_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R30" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA_CDKN1A_B_ </ci>
<ci> _cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R31" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA_CDKN1A_B_ </ci>
<ci> _cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R32" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA_CDKN1A_B_ </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R33" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA_CDKN1A_B_ </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R34" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA_CDKN1A_B_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA_CDKN1A_B_ </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R35" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>