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v4.0.0_optimized.sbml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" level="3" version="1">
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<vCard:Given>Paul</vCard:Given>
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<vCard:ORG>
<vCard:Orgname>University of Oxford</vCard:Orgname>
</vCard:ORG>
<vCard:EMAIL>[email protected]</vCard:EMAIL>
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<parameter id="_InitialConc21" value="133239590" constant="true"/>
<parameter id="_InitialConc22" value="819445660" constant="true"/>
<parameter id="_InitialConc23" value="1132433.3" constant="true"/>
<parameter id="_InitialConc24" value="335108260" constant="true"/>
<parameter id="_InitialConc25" value="22950816" constant="true"/>
<parameter id="_InitialConc26" value="59042195000" constant="true"/>
<parameter id="_InitialConc27" value="452427730" constant="true"/>
<parameter id="_InitialConc28" value="1177804900" constant="true"/>
<parameter id="_InitialConc29" value="1110340400" constant="true"/>
<parameter id="_InitialConc30" value="59109660000" constant="true"/>
<parameter id="_InitialConc31" value="60070998000" constant="true"/>
<parameter id="_InitialConc32" value="149002040" constant="true"/>
<parameter id="_InitialConc33" value="49793694000" constant="true"/>
<parameter id="_InitialConc34" value="19785953" constant="true"/>
<parameter id="_InitialConc35" value="10406520000" constant="true"/>
<parameter id="_InitialConc36" value="60220000000" constant="true"/>
<parameter id="_InitialConc37" value="0" constant="true"/>
<parameter id="_InitialConc38" value="60220000000" constant="true"/>
<parameter id="_InitialConc39" value="298.089" constant="true"/>
<parameter id="_InitialConc40" value="60220000000" constant="true"/>
<parameter id="_InitialConc41" value="13986043000" constant="true"/>
<parameter id="_InitialConc42" value="1112806800" constant="true"/>
<parameter id="_InitialConc43" value="2293289.4" constant="true"/>
<parameter id="_InitialConc44" value="423255970" constant="true"/>
<parameter id="_InitialConc45" value="113355900" constant="true"/>
<parameter id="_InitialConc46" value="4303401400" constant="true"/>
<parameter id="_InitialConc47" value="9065434" constant="true"/>
<parameter id="_InitialConc48" value="5277842600" constant="true"/>
<parameter id="_InitialConc49" value="50629691000" constant="true"/>
<parameter id="_InitialConc50" value="4648479700" constant="true"/>
<parameter id="_InitialConc51" value="242609110000" constant="true"/>
<parameter id="_InitialConc52" value="13847757000" constant="true"/>
<parameter id="_InitialConc53" value="4208780500" constant="true"/>
<parameter id="_InitialConc54" value="3799343900" constant="true"/>
<parameter id="_InitialConc55" value="42969631000" constant="true"/>
<parameter id="_InitialConc56" value="34406152" constant="true"/>
<parameter id="_InitialConc57" value="9702831900" constant="true"/>
<parameter id="_InitialConc58" value="6560445900" constant="true"/>
<parameter id="_InitialConc59" value="43226888" constant="true"/>
<parameter id="_InitialConc60" value="133239590" constant="true"/>
<parameter id="_InitialConc61" value="819445660" constant="true"/>
<parameter id="_InitialConc62" value="1132433.3" constant="true"/>
<parameter id="_InitialConc63" value="335108260" constant="true"/>
<parameter id="_InitialConc64" value="22950816" constant="true"/>
<parameter id="_InitialConc65" value="11461.427" constant="true"/>
<parameter id="_InitialConc66" value="6010538.6" constant="true"/>
<parameter id="_InitialConc67" value="6017412.1" constant="true"/>
<parameter id="_InitialConc68" value="4587.8816" constant="true"/>
<parameter id="_InitialConc69" value="59042195000" constant="true"/>
<parameter id="_InitialConc70" value="452427730" constant="true"/>
<parameter id="_InitialConc71" value="1177804900" constant="true"/>
<parameter id="_InitialConc72" value="1110340400" constant="true"/>
<parameter id="_InitialConc73" value="59109660000" constant="true"/>
<parameter id="_InitialConc74" value="60070998000" constant="true"/>
<parameter id="_InitialConc75" value="149002040" constant="true"/>
<parameter id="_InitialConc76" value="49793694000" constant="true"/>
<parameter id="_InitialConc77" value="19785953" constant="true"/>
<parameter id="_InitialConc78" value="10406520000" constant="true"/>
<parameter id="_InitialConc79" value="5087326.8" constant="true"/>
<parameter id="_InitialConc80" value="5087326.8" constant="true"/>
<parameter id="_InitialConc81" value="5087326.8" constant="true"/>
<parameter id="_InitialConc82" value="5087326.8" constant="true"/>
<parameter id="_InitialConc83" value="5087326.8" constant="true"/>
<parameter id="_InitialConc84" value="934673.17" constant="true"/>
<parameter id="_InitialConc85" value="934673.17" constant="true"/>
<parameter id="_InitialConc86" value="934673.17" constant="true"/>
<parameter id="_InitialConc87" value="934673.17" constant="true"/>
<parameter id="_InitialConc88" value="934673.17" constant="true"/>
<parameter id="_InitialConc89" value="0" constant="true"/>
<parameter id="_InitialConc90" value="0" constant="true"/>
<parameter id="_InitialConc91" value="0" constant="true"/>
<parameter id="_InitialConc92" value="0" constant="true"/>
<parameter id="_InitialConc93" value="0" constant="true"/>
<parameter id="_InitialConc94" value="60220000000" constant="true"/>
<parameter id="_InitialConc95" value="0" constant="true"/>
<parameter id="_InitialConc96" value="6022000" constant="true"/>
<parameter id="_InitialConc97" value="60220000000" constant="true"/>
<parameter id="_InitialConc98" value="6022000" constant="true"/>
<parameter id="_rateLaw1" value="0" constant="true"/>
<parameter id="tCCNE" constant="false"/>
<parameter id="tCCNA" constant="false"/>
<parameter id="tCCNB" constant="false"/>
<parameter id="tCDKN1A" constant="false"/>
<parameter id="tCDKN1B" constant="false"/>
<parameter id="tSKP2" constant="false"/>
<parameter id="ApcCdh" constant="false"/>
<parameter id="aCCNB" constant="false"/>
</listOfParameters>
<listOfRules>
<assignmentRule variable="tCCNE">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _Cyt__CCNE_CDKN1A_B_ </ci>
<ci> _Nuc__CCNE_CDKN1A_B_ </ci>
<ci> _Cyt__CCNE_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Cyt__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _Nuc__CCNE_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Cyt__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
<ci> _Nuc__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _Nuc__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tCCNA">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _Cyt__CCNA_CDKN1A_B_ </ci>
<ci> _Nuc__CCNA_CDKN1A_B_ </ci>
<ci> _Cyt__CCNA_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Cyt__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _Nuc__CCNA_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Cyt__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
<ci> _Nuc__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _Nuc__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tCCNB">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _Cyt__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_ </ci>
<ci> _Cyt__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_ </ci>
<ci> _Nuc__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_ </ci>
<ci> _Nuc__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_ </ci>
<ci> _Cyt__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Cyt__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Nuc__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Nuc__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tCDKN1A">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _Cyt__CDKN1A_CCNE_A_B_Ser130u_ </ci>
<ci> _Cyt__CCNA_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Cyt__CCNE_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Cyt__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Cyt__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Cyt__CDKN1A_CCNE_A_B_Ser130p_ </ci>
<ci> _Nuc__CDKN1A_CCNE_A_B_Ser130u_ </ci>
<ci> _Nuc__CCNA_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Nuc__CCNE_CDKN1A_B_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Nuc__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Nuc__CCNB_CDK1_Thr14_Tyr15p_CDKN1A_1__CDKN1A_CCNE_A_B_1_Ser130u_ </ci>
<ci> _Nuc__CDKN1A_CCNE_A_B_Ser130p_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tCDKN1B">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _Cyt__CDKN1B_CCNE_A_Thr187u_ </ci>
<ci> _Cyt__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _Cyt__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _Cyt__CDKN1B_CCNE_A_Thr187p_ </ci>
<ci> _Nuc__CDKN1B_CCNE_A_Thr187u_ </ci>
<ci> _Cyt__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
<ci> _Nuc__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _Cyt__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
<ci> _Nuc__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187u_ </ci>
<ci> _Nuc__CDKN1B_CCNE_A_Thr187p_ </ci>
<ci> _Nuc__CCNA_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
<ci> _Nuc__CCNE_CDKN1A_B_1__CDKN1B_CCNE_A_1_Thr187p_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tSKP2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _Cyt__SKP2 </ci>
<ci> _Nuc__SKP2 </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="ApcCdh">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _Cyt__APC_FBXO5_FZR1_CDC20_1_Ser355u__FZR1_APC_1_FBXO5_nTermu_ </ci>
<ci> _Cyt__APC_FBXO5_FZR1_CDC20_1_Ser355p__FZR1_APC_1_FBXO5_nTermu_ </ci>
<ci> _Nuc__APC_FBXO5_FZR1_CDC20_1_Ser355u__FZR1_APC_1_FBXO5_nTermu_ </ci>
<ci> _Nuc__APC_FBXO5_FZR1_CDC20_1_Ser355p__FZR1_APC_1_FBXO5_nTermu_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="aCCNB">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _Cyt__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_ </ci>
<ci> _Nuc__CCNB_CDK1_Thr14_Tyr15u_CDKN1A_ </ci>
</apply>
</math>
</assignmentRule>
</listOfRules>
<listOfReactions>
<reaction id="R1" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="_Cyt__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kSyE2f1 </ci>
<ci> Cyt </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R2" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__FOXM1_DBD_Thr600p_" stoichiometry="1" constant="true"/>
<speciesReference species="_Nuc__CCNB_promoter_FOXM1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kAsFPcb </ci>
<ci> _Nuc__FOXM1_DBD_Thr600p_ </ci>
<ci> _Nuc__CCNB_promoter_FOXM1_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R3" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__FOXM1_DBD_Thr600p_" stoichiometry="1" constant="true"/>
<speciesReference species="_Nuc__CCNB_promoter_FOXM1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDiFPcb </ci>
<ci> _Nuc__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R4" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Cyt__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_Nuc__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kSyE2f2 </ci>
<ci> _Nuc__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R5" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Cyt__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_Nuc__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kSyE2f2 </ci>
<ci> _Nuc__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R6" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Cyt__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Cyt__E2F_DBD_RB1_Ser332u_ </ci>
<ci> Cyt </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R7" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Cyt__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Cyt__E2F_DBD_RB1_Ser332p_ </ci>
<ci> Cyt </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R8" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Cyt__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Cyt__RB1_E2F_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Cyt__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
<ci> Cyt </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R9" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Cyt__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Cyt__RB1_E2F_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Cyt__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
<ci> Cyt </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R10" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__E2F_DBD_RB1_Ser332u_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R11" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__E2F_DBD_RB1_Ser332p_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R12" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__RB1_E2F_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R13" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__RB1_E2F_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R14" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__CCNE_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R15" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__CCNA_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R16" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__E2F_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R17" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__FBXO5_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R18" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__FOXM1_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R19" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__CCNE_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R20" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__CCNA_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R21" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__E2F_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R22" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_Nuc__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_Nuc__FBXO5_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _Nuc__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_ </ci>
<ci> Nuc </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R23" reversible="false" fast="false">